01 - Preheat the oven to 350°F. Grease a standard 12-cup muffin tin generously with butter or nonstick spray, or line each cup with paper liners.
02 - In a medium bowl, toss the diced rhubarb with 1/2 cup granulated sugar and 2 tablespoons melted butter until the fruit is evenly coated. Spoon approximately 1 to 2 tablespoons of this mixture into the bottom of each muffin cup, spreading it into an even layer.
03 - In a large mixing bowl, whisk together the flour, 3/4 cup granulated sugar, baking powder, baking soda, and salt until well blended and free of lumps.
04 - In a separate bowl, whisk together the cooled melted butter, eggs, whole milk, and vanilla extract until smooth and fully emulsified.
05 - Pour the wet ingredient mixture into the dry ingredients. Using a rubber spatula, fold gently until just combined — a few small streaks of flour are fine. Avoid overmixing to keep the muffins tender.
06 - Divide the batter evenly among the 12 muffin cups, spooning it directly over the rhubarb topping layer. Fill each cup about three-quarters full.
07 - Bake on the center rack for 23 to 25 minutes, until the tops are golden brown and a wooden toothpick inserted into the center of a muffin comes out clean.
08 - Allow the muffins to rest in the tin for 5 minutes. Run a thin knife around the edge of each muffin, then carefully invert the tin onto a wire rack to release the muffins so the caramelized rhubarb topping faces upward.
09 - Serve warm or at room temperature. These muffins are best enjoyed the same day but can be stored in an airtight container for up to 2 days.